Quinolines and derivatives

Medchemexpress LLC Disuccinimidyl sulfoxide | 1351828-03-9 | MFCD30497419 | 99.8% | 388.35 g·mol⁻¹ | C14H16N2O9S | 100MG

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Disuccinimidyl sulfoxide (DSSO) is a homobifunctional, amine-targeting sulfoxide cross-linker designed for mass-spectrometry-based protein cross-linking and interaction mapping. Its CID-cleavable bonds produce characteristic fragmentation patterns that simplify identification of cross-linked peptides, making it suitable for studies of peptides, proteins, and multisubunit complexes.

• MS-cleavable cross-linker that aids peptide identification
• Homobifunctional, amine-reactive chemistry for lysine targeting
• CID-cleavable sites generate characteristic fragmentation patterns
• Suitable for peptides, proteins, and multisubunit complexes
• Supplied as a crystalline solid for solution preparation
• High purity for analytical mass spectrometry

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Medchemexpress LLC Recombinant rat B7-H2 (ICOS ligand) protein, His tag | 100 UG

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Recombinant rat B7-H2 (ICOS ligand) protein expressed in HEK293 cells with a C-terminal His tag. Supplied as a purified recombinant protein for research use, it is suitable for biochemical assays, receptor binding studies, and assay development involving the ICOS pathway. Refer to the supplier datasheet for formulation, purity, and storage instructions.

• Suitable for biochemical assays, ELISA, and receptor binding studies.
• Expressed in mammalian cells to preserve native folding and glycosylation.
• C-terminal His tag facilitates purification and detection.
• Provided as purified protein; check the datasheet for formulation and endotoxin level.
• Intended for research use only, not for clinical or diagnostic applications.

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Medchemexpress LLC DAPT | 208255-80-5 | 100.0% | 200 MG

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DAPT is a potent and orally active γ-secretase inhibitor. It inhibits the activation of Notch 1 signaling and induces cell differentiation, autophagy, and apoptosis. This compound exhibits neuroprotection activity and holds potential for the treatment of autoimmune and lymphoproliferative diseases, degenerative diseases, and various cancers.

• Inhibits γ-secretase with IC50s of 115 nM for total amyloid-β (Aβ) and 200 nM for Aβ42.
• Inhibits activation of Notch 1 signaling.
• Induces cell differentiation, autophagy, and apoptosis.
• Exhibits neuroprotection activity, particularly in cerebral ischemia models.
• Potential therapeutic agent for autoimmune and lymphoproliferative diseases.
• Potential therapeutic agent for degenerative diseases and cancers.
• Useful in research for Alzheimer's disease, cell differentiation, autophagy, and apoptosis.

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Medchemexpress LLC Dactolisib | 915019-65-7 | >99% | C30H23N5O | 200 MG

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Dactolisib (BEZ235) is an orally active, dual pan-class I PI3K, and mTOR kinase inhibitor. It inhibits both mTORC1 and mTORC2, demonstrating potent activity against PI3K in an ATP competitive manner. This compound is known to reduce phosphorylation levels of mTOR activated kinase p70S6K and S235/S236P-RPS6.

• Dual pan-class I PI3K and mTOR kinase inhibitor
• Orally active
• Inhibits both mTORC1 and mTORC2
• Potently inhibits PI3K in an ATP competitive manner
• Effective in reducing phosphorylation levels of p70S6K and S235/S236P-RPS6

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Medchemexpress LLC Ipragliflozin L-Proline | 951382-34-6 | 99.9% | 519.58 | 200 MG

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Ipragliflozin (L-Proline) is a highly potent and selective SGLT2 inhibitor with an IC50 of 2.8 nM, showing little to no potency for SGLT1/3/4/5/6. It is intended for research use only.

• Potently and selectively inhibits human, rat, and mouse SGLT2.
• Exhibits stability against intestinal glucosidases.
• Shows good pharmacokinetic properties following oral dosing.
• Dose-dependently increases urinary glucose excretion.
• Reduces blood glucose and plasma insulin levels.
• Improves glucose intolerance.

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Medchemexpress LLC Ulixertinib (Standard) | 869886-67-9 | 99.9% | 433.33 | 200 MG

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Ulixertinib is a potent, orally active, and highly selective ATP-competitive, reversible covalent inhibitor of ERK1/2 kinases. It effectively inhibits ERK2 with an IC50 of <0.3 nM, reducing phosphorylated ERK2 (pERK) and downstream kinase RSK (pRSK) activity in A375 melanoma cells.

• Potent, orally active, and highly selective
• ATP-competitive and reversible covalent inhibitor of ERK1/2 kinases
• Inhibits ERK2 with an IC50 of <0.3 nM
• Reduces phosphorylated ERK2 (pERK) and downstream kinase RSK (pRSK) activity
• Demonstrates antiproliferative activity in various cell lines
• Investigated in clinical trials for multiple conditions, including solid tumors and various cancers

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Medchemexpress LLC Sulfo-ara-F-NMN | 1374663-29-2 | 99.4% | 352.28 | 50 MG

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Sulfo-ara-F-NMN (CZ-48) is a mimetic of nicotinamide mononucleotide (NMN) that selectively activates SARM1 and inhibits CD38 (IC50 around 10 μM). It induces intracellular cyclic ADP-ribose (cADPR) production and is intended for research use only.

• Selectively activates SARM1
• Inhibits CD38
• Induces intracellular cyclic ADP-ribose (cADPR) production
• Appears as a white to light yellow solid
• Store at -20°C under nitrogen
• Compound is unstable in solutions; freshly prepared is recommended

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Medchemexpress LLC B7-H2/ICOSLG Mouse 1mg

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B7-H2/ICOSLG is an important ligand of the T cell receptor ICOS and mediates immune responses It acts as a costimulatory signal promoting T and B cell proliferation cytokine secretion and plasma cell differentiation B7-H2/ICOSLG Protein Mouse (HEK293 His) is the recombinant mouse-derived B7-H2/ICOSLG protein expressed by HEK293 with C-His labeled tag

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